Systemic Proteomic Alterations and Predictive Biomarkers of Paroxetine Response in Refractory Rosacea: A Secondary Analysis of a Randomized Clinical Trial

B. Wang, X. Deng, Y. Zhang, X. Xiao, D. Jian, W. Shi, F. Liu, Z. Zhao, Y. Tang, M. Chen, Z. Deng, J. Li, Y. Huang, J. Huang, and Y. Zhang

doi:10.1001/jamadermatol.2026.1437

Abstract

Rosacea is a chronic inflammatory cutaneous disorder characterized by persistent erythema and vascular dysregulation. While paroxetine has shown clinical efficacy in reducing these symptoms, the systemic molecular mechanisms underlying its therapeutic response remain poorly characterized.

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