Tranexamic acid protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30/MAPK pathway

Y. Lin, Y. Wang, W. Wang, Z. Deng, Y. Zhang, Y. Peng, J. Tang, J. Li, C. Huang, and D. Jian

doi:10.1080/07853890.2026.2663263

Abstract

Tranexamic acid (TXA) is widely used for pigmentary disorders, but its anti-ageing potential remains unclear. This study aimed to evaluate whether topical 3% TXA improves early periorbital wrinkles in women with facial melasma and to investigate whether TXA protects human dermal fibroblasts from D-galactose-induced senescence

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