Depletion of CD147 sensitizes human malignant melanoma cells to hydrogen peroxide-induced oxidative stress

J. Li, L. Peng, L. Wu, Y. Kuang, J. Su, M. Yi, X. Hu, D. Li, H. Xie, T. Kanekura, and X. Chen

doi:10.1016/j.jdermsci.2010.03.022

Abstract

Increased sensitivity to reactive oxygen species (ROS) contributes to the effectiveness of therapeutic strategies in patients with malignant melanoma (MM). CD147, a cell surface receptor for cyclophilin A (CypA), is thought to exert antioxidant activities.

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