Thalidomide ameliorates rosacea-like skin inflammation and suppresses NF-κB activation in keratinocytes

M. Chen, H. Xie, Z. Chen, S. Xu, B. Wang, Q. Peng, K. Sha, W. Xiao, T. Liu, Y. Zhang, J. Li, and Z. Deng

doi:10.1016/j.biopha.2019.109011

Abstract

Rosacea is a chronic inflammatory skin disorder of uncertain etiology. Evidence suggests the underlying pathogenesis is modulated by abnormal inflammatory and vascular responses. Thalidomide is a synthetic derivative acid with anti-inflammatory and anti-angiogenic properties. However, its effects on rosacea remain unknown.

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